The role of SIRT3 in regulating cancer cell metabolism
نویسندگان
چکیده
Background Sirtuins are a family of NAD-dependent deacetylase, deacylase, and/or mono-ADP ribosyltransferase enzymes involved in regulation of many biological processes. Mammals contain seven sirtuins, three of which are localized to the mitochondria (SIRT3-5). SIRT3 has been shown to be the major mitochondrial deacetylase that regulates metabolic enzymes and promotes oxidative metabolism and energy production. Loss of one copy of the SIRT3 gene is observed in various human cancers. Thus, we examined the role of SIRT3 in regulating metabolism in cancer cells.
منابع مشابه
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2012